Diagnostic, Prognostic and Therapeutic Value of Gene Signatures

Diagnostic, Prognostic and Therapeutic Value of Gene Signatures

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Gene expression studies have revealed diagnostic profiles and upregulation of specific pathways in many solid tumors. The explosion of new information in gene expression profiling could potentially lead to the development of tailored treatments in many solid tumors. In addition many studies are ongoing to validate these signatures also in predicting response to hormonal, chemotherapeutic and targeted agents in breast cancer as well as in other tumors. Diagnostic, Prognostic and Therapeutic Value of Gene Signatures provides readers a useful and comprehensive resource about the range of applications of microarray technology in oncological diseases. Topics covered include gene signatures and soft tissue sarcomas, prognostic relevance of breast cancer signatures, gene expression profiling of colorectal cancer and liver metastasis, gene signatures in GISTs, CNVs and gene expression profiles in pancreatic cancer, and gene signatures in head/neck, lung and gastric tumors. Diagnostic, Prognostic and Therapeutic Value of Gene Signatures will be of great value to residents and fellows, physicians, pathologists and medical oncologists.Establishment of a phylogenetic correlation between genomic alterations of tumors and their metastases allowed drawing a kinetic of tumor progression [220] . Unexpectedly, the ... A diagram summarizing these data is represented in Fig. 5.2.


Title:Diagnostic, Prognostic and Therapeutic Value of Gene Signatures
Author: Antonio Russo, Stefano Iacobelli, Juan Iovanna
Publisher:Springer Science & Business Media - 2011-11-03
ISBN-13:

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